We study the optical properties of Molybdenum Disulphide nanosheets deposited by chemical vapor deposition onto a nanopatterned substrate endowed with a uniaxial corrugation. The uniaxial nanocorrugation leads to a polarization dependence in steady state and an anisotropic relaxation around the C resonance. Finite element numerical simulations allow to better disclose the scenario. Our findings point towards new possibilities for the manipulation of the optical properties of two-dimensional transition metal dichalcogenides via substrate nanopatterning.